Antioxidant Capacity and Potential as an Alpha-Glucosidase Inhibitor in Phaleria macrocarpa (Scheff.) Boerl Fruit Peel Ultrasonic Extract

Phaleria macrocarpa (Scheff.) Boerl is native to the tropical region of Papua Island, Indonesia, and has traditionally been used as a herbal drink, either alone or in combination with other medicinal plants, treat diseases such cancer, hypertension, diabetes mellitus. This study aimed obtain fruit peel extract Boerl. through application ultrasound-assisted extraction (UAE) variations time amplitude produce optimal conditions. The potential an antioxidant using cupric ion reducing capacity (CUPRAC) ferric power (FRAP) methods, its antidiabetic alpha glucosidase inhibition. optimum selected was C (extraction 45 minutes 60%) IC50 values for activity CUPRAC method 39.63 ± 0.009 mg/L FRAP 77.37 0.8 mg/L, while inhibition 0.45 0.007 mg/L. It can be concluded that ethanol source antioxidants anti-diabetic.